Facile preparation of 3-substituted-2,6-difluoropyridines: application to the synthesis of 2,3,6-trisubstituted pyridines
2015
Katoh, Taisuke | Tomata, Yoshihide | Tsukamoto, Tetsuya | Nakada, Yoshihisa
We report a facile method for the difluorination of 3-substituted-2,6-dichloropyridines using cesium fluoride as a fluorination reagent in dimethyl sulfoxide. It is proposed that this method for preparing 3-substituted-2,6-difluoropyridines is simpler and easier than those reported in previous literature. To examine the utility of 3-substituted-2,6-difluoropyridines in synthetic chemistry, we also demonstrate a subsequent conversion to 2,3,6-trisubstituted pyridines by a tandem nucleophilic aromatic substitution.
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书目信息
出版者
Elsevier Ltd
其它主题
Dimethyl sulfoxide; 6-trisubstituted pyridines; 6-difluoropyridines; 3-substituted-2; Difluorination
语言
英语
类型
Journal Article; Text
2024-02-28
MODS