Synthesis of Kappa Opioid Antagonists Based On Pyrrolo[1,2-α]quinoxalinones Using an N-Arylation/Condensation/Oxidation Reaction Sequence
2016
Scarry, Sarah M. | Lovell, Kimberly M. | Frankowski, Kevin J. | Bohn, Laura M. | Aubé, Jeffrey
The quinoxaline and quinoxalinone family of nitrogen heterocycles is present in molecules of therapeutic relevance for diverse applications ranging from infectious diseases to neuroscience targets. Here, we describe a general synthetic sequence to afford pyrrolo[1,2-α]quinoxalinones from commercially available starting materials and their use in preparing potential kappa opioid receptor antagonists. The biological data obtained from the latter set of compounds is briefly presented and discussed.
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书目信息
出版者
American Chemical Society
其它主题
Organic chemistry; Antagonists
语言
英语
许可
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类型
Journal Article; Text
2024-02-28
MODS