Drug-induced stabilisation of a mismatched C-T base pair in a DNA hairpin

Gallagher, Cathal T.; Searle, Mark S.

Drug-induced stabilisation of a mismatched C-T base pair in a DNA hairpin

2003

Gallagher, Cathal T. | Searle, Mark S.

We have shown that a key feature of drug binding, namely specific G-C base pair recognition at a 5′-TG step, can induce a number of novel structural features when an extrahelical base is inserted in close proximity to the drug binding site; we have clearly demonstrated the formation of a stabilised C-T mismatched base pair at a non-terminal site.

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