A Tracer method for measuring glucose absorption rates
1983
A double-isotope method for measuring the intestinal uptake of glucose in a non-steady state has been developed for clinical investigatioin usage. Glucose is rapidly and virtually removed from the intestinal human, and only in rare instances does it remain in the intestine. Tests used to determine its presence in the intestine are difficult, lengthy, and cumbersome. The new method utilizes an oral dose of isotopically labeled glucose taken 2 hours after the initiation of a 6-hour intravenous infusion of saline and glucose labeled with another isotope. Rates of sugar uptake by the gut and the disappearance of glucose from the blood are combined into a mathematical model describing the quantitative pattern of absorption. The nutritional applications of a tracer technique could substantially exercise understanding of the rate, extent, and duration of glucose appearance after meal consumption. Two other areas of application may be in determining the effects of dietary fiber components on the rate of glucose uptake and stimulation of insulin release. (kbc)
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