One-Step Synthesis of Aliphatic Potassium Acyltrifluoroborates (KATs) from Organocuprates

Liu, Sizhou M.; Wu, Dino; Bode, J. W.

One-Step Synthesis of Aliphatic Potassium Acyltrifluoroborates (KATs) from Organocuprates

2018

Liu, Sizhou M. | Wu, Dino | Bode, J. W. (Jeffrey W.)

A one-step synthesis of aliphatic KATs from organocuprates is reported. Organolithium and organomagnesium reagents were readily transmetalated onto Cu(I) and coupled with a KAT-forming reagent to yield the respective aliphatic KAT. The protocol is suitable for primary, secondary and—for the first time—tertiary alkyl substrates. These protocols considerably expand the range of KATs that can be readily accessed in one step from commercially available starting materials.

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