A mycophenolic acid derivative from the fungus Penicillium sp. SCSIO sof101
2020
Song, Xiaoxian | Tu, Ruxia | Mei, Xiaoli | Wu, Silan | Lan, Bo | Zhang, Li | Luo, Xianqin | Liu, Jianyi | Luo, Minghe
Mycophenolic acid (MPA) is a group of metabolite derived from several species of Penicillium, which shows potent bioactivity. In this study, a new derivative of MPA compound named penicacid D (1), was isolated from the marine derived fungus Penicillium sp. SCSIO sof101, along with seven known compounds (2-8). Their structures were elucidated based on the HR-ESI-MS and NMR data. Moreover, the ¹H and ¹³C NMR data of compound 2 and the ¹³C NMR data of compound 3 are reported. Compounds 1, 4 and 6 exhibited weak activities against Escherichia coli (clinical isolation number 100385570) and Acinetobacter baumannii (clinical isolation number 100069).
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