Generation of wavy structure on lipid membrane by peripheral proteins: a linear elastic analysis
2017
Mahata, Paritosh | Das, Sovan Lal
We carry out a linear elastic analysis to study wavy structure generation on lipid membrane by peripheral membrane proteins. We model the lipid membrane as linearly elastic and anisotropic material. The hydrophobic insertion by proteins into the lipid membrane has been idealized as penetration of rigid rod‐like inclusions into the membrane and the electrostatic interaction between protein and membrane has been modeled by a distributed surface traction acting on the membrane surface. With the proposed model we study curvature generation by several binding domains of peripheral membrane proteins containing BAR domains and amphipathic alpha‐helices. It is observed that electrostatic interaction is essential for curvature generation by the BAR domains.
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