Asymmetric Retro-Claisen Reaction by Synergistic Chiral Primary Amine/Palladium Catalysis
2019
Han, Yanfang | Zhang, Long | Luo, Sanzhong
We described herein a chiral primary amine/palladium catalyzed asymmetric retro-Claisen reaction of β-diketones with salicylic carbonates. A series of chiral α-alkylated ketones and macrolides were obtained with good yields and excellent enantioselectivities upon a sequence of decarboxylative benzylation, retro-Claisen cleavage, and enamine protonation. This strategy features broad substrate scope, mild conditions, as well as high atom economy with salicylic carbonates as the o-quinone methide precursors.
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书目信息
出版者
American Chemical Society
其它主题
Enantioselectivity; Enamines; Protonation; Benzylation; Macrolides
语言
英语
类型
Journal Article; Text
2024-02-28
MODS