Design of a new oligotriazole peptide nucleic acid analogue (oT-PNA)

Vergnaud, Julien; Faugeras, Pierre-Antoine; Chaleix, Vincent; Champavier, Yves; Zerrouki, Rachida

Design of a new oligotriazole peptide nucleic acid analogue (oT-PNA)

2011

Vergnaud, Julien | Faugeras, Pierre-Antoine | Chaleix, Vincent | Champavier, Yves | Zerrouki, Rachida

We describe in this Letter the synthesis of an original thymine azido-heterotrimer generated by Click Chemistry. This trimer has been obtained from an azido-thymidine and a new chloroethyl-propargylated PNA monomer analogue, after two azidation/click-reaction cycles. Conformational preferences of a rotameric intermediate have also been studied.

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