Zinc transport by transferrin in rat portal blood plasma
1975
Evans, G.W. | Winter, T.W.
Zinc transport in mesenteric lymph and zinc distribution in portal plasma and venous plasma were examined in rats that had been given an oral dose of65Zn. Less than 1% of an oral dose of65Zn appeared in the mesenteric lymph over a period of 8 hr. In portal plasma, approximately 70% of the isotope recovered after gel filtration chromatography was bound to a protein that was identified as transferrin on the basis of molecular weight and electrophoretic properties. In venous plasma, the major fraction of65Zn was bound to albumin while the remainder of the isotope was associated with higher molecular weight proteins including transferrin and α2 macroglobulins. These results demonstrate that zinc is transported from the intestine to the liver via the portal blood, and the results demonstrate that zinc is transported in portal plasma bound to transferrin.
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