Controlled Solid Phase Peptide Bond Formation Using N-Carboxyanhydrides and PEG Resins in Water
2013
De Marco, Rossella | Tolomelli, Alessandra | Greco, Arianna | Gentilucci, Luca
The increasing need for large quantities of biologically active peptides for the market strongly raised the problem of the environmental sustainability of their synthesis. In this respect, we describe herein a solid phase procedure in water, using PEG peptide amide resins and NCAs under controlled conditions. This procedure afforded with reasonable yield and purity a short peptide amide, without the need of coupling reagents or protecting groups.
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书目信息
出版者
American Chemical Society
其它主题
Microwave irradiation; Peg resin; Environmental sustainability; Unprotected amino acids; Aqueous; Solid phase peptide synthesis; N-carboxyanhydride; Peptide amide
语言
英语
类型
Journal Article; Text
2024-02-28
MODS