Zinc intestinal absorption: effect of carbohydrates
1989
Wapnir, R.A. | Stiel, L. | Lee, S.Y.
We investigated the role of some simple and complex carbohydrates (CHO) on the luminal phase of Zn absorption from rat jejunum, using an open perfusion system and basal solutions containing 0.15 mM (10 mg/L) Zn and 0.30 mM L-histidine, in the presence of either no CHO or 50 mOsm/kg of either glucose (GLU), fructose (FRU), lactose (LAC), or corn syrup solids (CSS). The latter was also studied at 10 mOsm/kg. GLU, FRU, and low level CSS enhanced Zn absorption, but neither LAC nor high level CSS had an effect. GLU and CSS increased net water and sodium absorption. The absolute amount of CHO absorbed did not correlate with Zn absorption. When either GLU or high level CSS were present, there was a positive correlation between net water and zinc absorption (r= 0.652, P less than 0.05; r= 0.890, P less than 0.001, respectively). Conclusions: the stimulation of Zn absorption by GLU and low levels of CSS is associated with greater water and sodium absorption. With FRU, enhancement of Zn absorption may involve other mechanisms. Excess unhydrolyzed GLU polymers (high level CSS) and slowly absoarbed sugars (LAC), may limit Zn absorption.
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