Short term food supplementation effects of a fish derived extract on the immunological status of pregnant rats and their sucking pups
2001
Lombardi, V.R.M. | Cagiao, A. | Fernandez-Novoa, L. | Alvarez, X.A. | Corzo, M.D. | Zas, R. | Sampedro, C. | Cacabelos, R.
There is emerging evidence that PUFAs influence immune functions by controlling the normal inflammatory process and may do so by serving as a signal modulator that regulates specific enzymatic activities typically elevated during inflammation at the inflammation site. In the present study, the effect of 12 weeks food supplementation with E-SAR 94010, a marine fish extract, before and during pregnancy and lactation in Sprague-Dawley rats and their offspring was investigated. Triglyceride plasma levels of pups and their mothers was lower in the treated groups than in the control group. No significant differences in the atherogenic index (total cholesterol-HDLcholesterol/HDLcholesterol) were observed. Studies on the lymphocyte cell marker suggest a clear immune activation as measured by the increased levels of CD25, CD28, CD54, CD62 and CD56 on lymphocytes derived from both E-SAR treated mothers and newborns. Therefore the present results indicate that E-SAR-94010 dietary supplementation can be responsible for an increased level of immune surveillance.
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