Brønsted acid−catalyzed synthesis of tetrasubstituted allenes and polysubstituted 2H-chromenes from tertiary propargylic alcohols
2019
Cabrera-Lobera, Natalia | Velasco, Noelia | Sanz, Roberto | Fernández-Rodríguez, Manuel A.
A practical and environmentally benign Brønsted acid−catalyzed protocol for the preparation of all-carbon tetrasubstituted allenes, consisting in the direct SNˈ addition of tri- or dimethoxy arenes or allyltrimethylsilane to tertiary propargylic alcohols, has been developed. In addition, a straightforward synthesis of densely substituted 2H-chromenes by metal-free tandem allenylation/heterocyclization reaction of methoxyphenols and tertiary alkynols is presented.
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书目信息
Tetrahedron
卷
75
期
31
页码
4071
- 4080
ISSN
0040-4020
出版者
Elsevier Ltd
其它主题
2h-chromenes; Brønsted acid catalysis; Nucleophilic substitution; Allenes; Propargylic alcohols
语言
英语
类型
Journal Article; Text
2024-02-28
MODS