Peculiarities of methemoglobin recovery system in erythrocytes of sterlet under nitrite intoxication
2015
Khuda, L. V. | Khudyi, O. I. | Marchenko, M. M.
The content of methemoglobin and the functional status of its recovery system in erythrocytes have been studied for the sterlet Acipenser ruthenus L. exposed to a sodium nitrite concentration ranging from 7.25 to 217.5 mmol/L. The functional features of methemoglobin reductase system form the basis of the specific accumulation of methemoglobin. High concentrations of nitrite in plasma inhibit hemo-containing enzymes (methemoglobin reductase and catalase) that normally prevent the excessive accumulation of methemoglobin. Under the conditions of nitrite intoxication, the leading role in the functioning of the methemoglobin reduction system belongs to its nonenzymatic components (reduced glutathione and ascorbate).
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