Minisci alkylations of electron-deficient pyrimidines with alkyl carboxylic acids
2015
Shore, Daniel G.M. | Wasik, Kimberly A. | Lyssikatos, Joseph P. | Estrada, Anthony A.
A practical method for the Minisci reaction of electron-deficient pyrimidines with carboxylic acids is described. The one-step protocol allows for the alkylation of halo- and trifluoromethyl pyrimidines with a variety of readily available alkyl and (hetero)cycloalkyl carboxylic acids. These conditions permitted the facile synthesis of substituted pyrimidines, which are poised for further elaboration through divergent means.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
出版者
Elsevier Ltd
其它主题
Radicals; Alkylation; Divergent synthesis; Minisci reaction
语言
英语
类型
Journal Article; Text
2024-02-28
MODS