Essential oil from the leaves of Xylopia langsdorfiana (Annonaceae) as a possible spasmolytic agent
2015
de C. Correia, Ana Carolina | Ferreira, Tamyris F. | Martins, Italo Rossi R. | Macêdo, Cibério L. | de S. Monteiro, Fabio | Costa, Vicente Carlos O. | Tavares, Josean F. | Silva, Marcelo S. | Paredes-Gamero, Edgar J. | Buri, Marcus V. | Rigoni, Vera L.S. | Nouailhetas, Viviane L.A. | Silva, Bagnólia A Da
Xylopia langsdorfiana A. St.-Hil. &Tul. (Annonaceae) is popularly known in the northeast of Brazil as ‘pimenteira da terra’, and an essential oil (XL-OE) was extracted from its leaves. Since Xylopia species are cited in folk medicine and diterpenes from X. langsdorfiana have spasmolytic activity, this study aimed to investigate a possible spasmolytic action of XL-OE on smooth muscle models. XL-OE (243 and 729 μg/mL) showed low pharmacologic efficacy on guinea pig trachea and rat aorta and uterus. However, in guinea pig ileum, XL-OE (27–729 μg/mL) inhibited carbachol or histamine-induced phasic contractions (1 μM) in a significant and concentration-dependent manner. In addition, XL-OE (81 μg/mL) reduced fluorescence intensity in ileal myocytes stimulated by histamine, indicating a decrease in cytosolic calcium concentration, which could explain the spasmolytic activity. Thus, XL-OE proved to be a promising natural product to be used in gastrointestinal diseases acting by modulating the cytosolic calcium concentration.
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