Fumonisin B₁ and risk of hepatocellular carcinoma in two Chinese cohorts
2012
Christina Persson, E. | Sewram, Vikash | Evans, Alison A. | Thomas London, W. | Volkwyn, Yvette | Shen, Yen-Ju | Van Zyl, Jacobus A. | Chen, Gang | Lin, Wenyao | Shephard, Gordon S. | Taylor, Philip R. | Fan, Jin-Hu | Dawsey, Sanford M. | Qiao, You-Lin | McGlynn, Katherine A. | Abnet, Christian C.
Fumonisin B₁ (FB₁), a mycotoxin that contaminates corn in certain climates, has been demonstrated to cause hepatocellular cancer (HCC) in animal models. Whether a relationship between FB₁ and HCC exists in humans is not known. To examine the hypothesis, we conducted case-control studies nested within two large cohorts in China; the Haimen City Cohort and the General Population Study of the Nutritional Intervention Trials cohort in Linxian. In the Haimen City Cohort, nail FB₁ levels were determined in 271 HCC cases and 280 controls. In the General Population Nutritional Intervention Trial, nail FB₁ levels were determined in 72 HCC cases and 147 controls. In each population, odds ratios and 95% confidence intervals (95%CI) from logistic regression models estimated the association between measurable FB₁ and HCC, adjusting for hepatitis B virus infection and other factors. A meta-analysis that included both populations was also conducted. The analysis revealed no statistically significant association between FB₁ and HCC in either Haimen City (OR=1.10, 95%CI=0.64–1.89) or in Linxian (OR=1.47, 95%CI=0.70–3.07). Similarly, the pooled meta-analysis showed no statistically significant association between FB₁ exposure and HCC (OR=1.22, 95%CI=0.79–1.89). These findings, although somewhat preliminary, do not support an associated between FB₁ and HCC.
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