Evaluation of the efficacy of whey protein to ameliorate the toxic effects of aflatoxins in rats
2007
Saleh, Z.A. | El-Garawany, G.A. | Assem, F. | El-Shibiny, S.
The present study was conducted to assess the ability of whey protein concentrate (WPC) to protect against aflatoxicosis. Three groups of Sprague-Dawley male rats were used. The control (a) was fed on casein diet, the control (b) received the same diet contaminated with aflatoxins (AFT; 2.5 mg AFB1 kg-1). The AFT-contaminated diet was supplemented with WPC and fed to the third group for 9 weeks. Compared with control (a) rats, those fed the contaminated diet (control b) showed significant drop (p<0.05) in body weight gains, food efficiency ratio (FER), an increase in the liver function enzymes, malondialdehyde level (MDA) and a decrease in blood glutathione (GSH), plasma calcium, magnesium and potassium. Addition of WPC to the AFT-contaminated diet realized better growth rate and FER and improved the above biochemical parameters. This study indicates that WPC supplementation appears beneficial to compensate AFT toxicity.
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