Total Synthesis of (−)-Luminacin D
2016
Malassis, Julien | Bartlett, Nathan | Hands, Kane | Selby, Matthew D. | Linclau, Bruno
A second-generation synthesis of (−)-luminacin D based on an early stage introduction of the trisubstituted epoxide group is reported, allowing access to the natural product in an improved yield and a reduced number of steps (5.4%, 17 steps vs 2.6%, 19 steps). A full account of the optimization work is provided, with the reversal of stereoselection in the formation of the C4 alcohol in equally excellent diastereoselectivity as the key improvement.
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书目信息
出版者
American Chemical Society
其它主题
Diastereoselectivity; Organic chemistry
语言
英语
类型
Journal Article; Text
2024-02-28
MODS