Anaerobicizing into Pluripotency

Panopoulos, Athanasia D.; Belmonte, Juan Carlos Izpisua

Anaerobicizing into Pluripotency

2011

Panopoulos, Athanasia D. | Belmonte, Juan Carlos Izpisua

Reprogramming involves multiple layers of molecular regulation, yet it remains relatively unknown how the cell's metabolism is changing and/or contributing to this process. In this issue of Cell Metabolism, Folmes et al. (2011) demonstrate that reprogramming induces a bioenergetic transition from an oxidative to a glycolytic state, and provide evidence to suggest that these changes may precede pluripotency.

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