Transition-metal-free, visible-light-mediated regioselective C–H trifluoromethylation of imidazo[1,2-a]pyridines
2019
Zhou, Qiguang | Xu, Song | Zhang, Ronghua
A transition-metal-free, visible-light-induced trifluoromethylation of imidazo[1,2-a]pyridines has been developed at mild conditions by employing cheap and commercially available anthraquinone-2-carboxylic acid (AQN-2-CO2H) as the photo-organocatalyst, and Langlois reagent as the trifluoromethylating reagent. A series of 3-(trifluoromethyl)imidazo[1,2-a]pyridine derivatives with broad functionalities could be conveniently and efficiently obtained by direct regioselective functionalization.
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书目信息
出版者
Elsevier Ltd
其它主题
Visible-light; Trifluoromethylation; Transition-metal-free; Imidazo[1; 2-a]pyridines; Regioselectivity
语言
英语
类型
Journal Article; Text
2024-02-28
MODS