MicroRNA-24 inhibits osteosarcoma cell proliferation both in vitro and in vivo by targeting LPAATβ
2013
Song, Lei | Yang, Jie | Duan, Ping | Xu, Jianzhong | Luo, Xiangdong | Luo, Fei | Zhang, Zehua | Hou, Tianyong | Liu, Bing | Zhou, Qiang
Lysophosphatidic Acid Acyltransferase β (LPAATβ) may be critically involved in osteosarcoma cell proliferation. However, the comprehensive mechanisms responsible for regulation of LPAATβ in osteosarcoma cells remain unclear. This study found that enhanced LPAATβ expression was correlated with osteosarcoma cell proliferation. MiR-24, targeted to LPAATβ, was down-regulated in osteosarcoma cells. Overexpression of miR-24 down-regulated LPAATβ expression in osteosarcoma cells. Specifically, overexpression of miR-24 inhibited osteosarcoma cell proliferation, however, such effect was blocked when LPAATβ activity was inhibited. In conclusion, our study indicates that miR-24 is reduced in osteosarcoma cells, contributing to up-regulation of LPAATβ and resultant osteosarcoma cell proliferation.
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