Enantioselective Intermolecular Enamide–Aldehyde Cross-Coupling Catalyzed by Chiral N-Heterocyclic Carbenes

Wu, Jicheng; Zhao, Changgui; Wang, Jian

Enantioselective Intermolecular Enamide–Aldehyde Cross-Coupling Catalyzed by Chiral N-Heterocyclic Carbenes

2016

Wu, Jicheng | Zhao, Changgui | Wang, Jian

The unprecedented N-heterocyclic carbene (NHC)-catalyzed intermolecular cross-coupling of enamides and aldehydes is described. Upon exposure of enamides to aldehydes in the presence of a NHC catalyst, catalytic C–C bond formation occurs, providing highly enantioselective N-protected amines, bearing a quaternary carbon center, in good yields and with high enantioselectivities.

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