Copper-promoted reductive homocoupling of quasi-aromatic iron(ii) clathrochelates: boosting the inhibitory activity in a transcription assay
2014
Varzatskii, O. A. | Novikov, V. V. | Shulga, S. V. | Belov, A. S. | Vologzhanina, A. V. | Negrutska, V. V. | Dubey, I. Y. | Bubnov, I︠U︡. N. (I︠U︡riĭ Nikolaevich) | Voloshin, Ya. Z.
A copper-promoted reductive homocoupling reaction, for the first time used for a metal complex, allowed obtaining a new kind of complexes with the encapsulated metal ions, C–C conjugated bis-clathrochelates. These compounds demonstrate extremely high transcription inhibition activity in the T7 RNA polymerase system with values of IC₅₀ reaching as low as the submicromolar range, which places them among the most potent metal-based transcription inhibitors.
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