Rhodium-Catalyzed Cyanation of C(sp2)–H Bond of Alkenes
2015
Chaitanya, Manthena | Anbarasan, Pazhamalai
Efficient and selective rhodium-catalyzed cyanation of chelation-assisted C–H bonds of alkenes has been accomplished using environmentally benign N-cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS) as a cyanating reagent. The developed methodology tolerates various functional groups and allows the synthesis of diverse substituted acrylonitriles in good to excellent yields. Furthermore, the potential of the methodology was demonstrated through the formal synthesis of chlorpheniramine-based antagonist.
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书目信息
出版者
American Chemical Society
其它主题
Alkenes; Antagonists; Chemical bonding; Moieties
语言
英语
类型
Journal Article; Text
2024-02-28
MODS