Structure and cytotoxicity of dehydrotomatine, a minor component of tomato glycoalkaloids

Ono, H.; Kozuka, D.; Chiba, Y.; Horigane, A.; Isshiki, K.

Structure and cytotoxicity of dehydrotomatine, a minor component of tomato glycoalkaloids

1997

Ono, H. | Kozuka, D. | Chiba, Y. | Horigane, A. | Isshiki, K.

The structure of dehydrotomatine was determined as (3 beta,22 beta,25S)-spirosol-5-en-3-yl-O-beta-D-glucopyranosyl-(1 leads to 2)-O-[beta-D-xylopyranosyl-(1 leads to 3)]-O-beta-D-glucopyranosyl-(1 leads to 4)-beta-D-galactopyranoside from the analysis of FAB-MS, UV, and NMR spectra. Dehydrotomatine exhibited cytotoxicity on animal cell lines HepG2, NIH/3T3, and U937 lower than that of tomatine, the major tomato glycoalkaloid.

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