Does inflammation play a role in kava hepatotoxicity
2011
Zhang, Lillian Yuan | Rowe, Anthony | Ramzan, Iqbal
The pathophysiology of kava hepatotoxicity remains inconclusive. There is circumstantial evidence for the roles of toxic metabolites, inhibition of cyclooxygenase (COX) enzymes and depletion of liver glutathione. Pharmacogenomic effects are likely, particularly for Cytochrome P450 genes. Experimental and clinical cases of hepatotoxicity show evidence of hepatitis. The question remains whether this inflammation is caused by components of kava directly, or indirectly due to the downstream effects.
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书目信息
出版者
John Wiley & Sons, Ltd.
其它主题
Chemical and drug induced liver injury; Hepatotoxicity; Cytochrome p-450
语言
英语
注释
Includes references
类型
Journal Article; Text
2024-02-28
MODS