Protein carbonyls and traditional biomarkers in pigs exposed to low-dose γ-radiation
2013
Smutná, Miriam | Beňová, Katarína | Dvořák, Petr | Nekvapil, Tomáš | Kopřiva, Vladimír | Maté, Dionýz
Response of pigs to irradiation manifested by production of protein carbonyls and adaptable enzymes was studied in two experiments. In one experiment, 10 mixed-sex pigs were exposed to 0.5Gy whole body 60Co irradiation. In the other experiment, another batch of 10 pigs was exposed to 1.0Gy half-body irradiation.Unlike those exposed to half-body irradiation, the pigs exposed to whole-body irradiation showed significant increase in protein carbonyls by 73%, and a decrease in cholesterol by 25.7%, compared to the control group. In both cases of dose-dependent irradiation exposure, pigs showed a decrease in alanine aminotransferase activity compared with the control group. At the dose of 1Gy, ALT activity decreased significantly by 27.7%. Aspartate aminotransferase activity in pigs after half-body irradiation decreased significantly by 65.5%. Although low doses of ionizing radiation were applied, monitoring of the above biochemical parameters helped define the pigs’ biological response.
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