Controlled synthesis of N, N-dimethylarylsulfonamide derivatives as nematicidal agents
2020
Chen, Gen-Qiang | Xia, Yan-Fei | Yang, Jin-Ming | Che, Zhi-Ping | Sun, Di | Li, Shen | Tian, Yue-E | Liu, Sheng-Ming | Jiang, Jia | Lin, Xiao-Min
Gramine can be intelligently and efficiently supplied with N, N-dimethylamino group and then reacted with the corresponding sulfonyl chlorides to synthesize N, N-dimethylarylsulfonamides. We herein designed and controlled synthesis of N, N-dimethylarylsulfonamide derivatives, and first reported the results of the nematicidal activity of 15 title compounds 3a-o against Meloidogyne incongnita in vitro, respectively. Among all of the title derivatives, compounds 3a, 3c, 3k, and 3o exhibited potent nematicidal activity with median lethal concentration (LC₅₀) values ranging from 0.22 to 0.26 mg/L. Most noteworthy, N, N-dimethyl-4-methoxyphenylsulfonamide (3c) and N, N-dimethyl-8-quinolinesulfonamide (3o) showed the best promising and pronounced nematicidal activity, with LC₅₀ values of 0.2381 and 0.2259 mg/L, respectively.
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