The pharmacokinetics of chloramphenicol in plasma and saliva of dairy cows
1990
DOTTER, A. | KROKER, R. | Arnold, D.
In the present study the pharmacokinetics of chloramphenicol were investigated in bovine plasma and saliva. The method of detection of chloramphenicol, a radioâimmunoassay, requires only small sample volumes, no further cleanâup, and a large number of samples can be processed simultaneously. This enabled the collection of a larger number of samples over a longer period of time than in previous studies. The intention was to obtain a complete pharmacokinetic profile of chloramphenicol, to evaluate it according to common openâcompartment models, and to compare it with the results of previous studies. The radioâimmunoassay results were confirmed by analysing a number of samples distributed over the concentration range of interest by a gasâchromatographic method with electronâcapture detection. The suitability of saliva was evaluated as a possible means of monitoring compliance with the ban on chloramphenicol in the Federal Republic of Germany in milkâproducing animals.
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