The yeast prohormone-processing Kex2 protease, an enzyme with specificity for paired basic residues

Fuller, R.S.; Brenner, C.; Gluschankof, P.; Wilcox, C.A.

The yeast prohormone-processing Kex2 protease, an enzyme with specificity for paired basic residues

1991

Fuller, R.S. | Brenner, C. | Gluschankof, P. | Wilcox, C.A.

The Kex2 protease of the yeast Saccharomyces cerevisiae and two recently discovered human homologues define a novel subfamily of subtilisin-related serine proteases that may be responsible for cleaving prohormones and other precursor polypeptides at paired basic residues in the eukaryotic secretory pathway. Here, the pathway of post-translational modification of Kex2 protease, its domain structure and primary sequence specificity are discussed.

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