Kanamycin A 6′-pyrenylamide: a selective probe for heparin detection

Nalage, Santosh V.; Bhosale, Sidhanath V.; Bhargava, Suresh K.; Bhosale, Sheshanath V.

Kanamycin A 6′-pyrenylamide: a selective probe for heparin detection

2012

Nalage, Santosh V. | Bhosale, Sidhanath V. | Bhargava, Suresh K. | Bhosale, Sheshanath V.

We have synthesized a novel derivative of kanamycin A bearing a pyrenyl fluorophore which can be used for the specific recognition of heparin in EtOH:H₂O (1:3) through formation of a 2:1 complex. The receptor shows specific optical signalling for heparin, but exhibits no significant changes on addition of various other biological molecules.

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