Synthesis and characterization of magnetic hybrid nanomaterials via RAFT polymerization: A pH sensitive drug delivery system
2019
Pourjavadi, Ali | Kohestanian, Mohammad | Shirzad, Mahdieh
Herein, a facile and versatile method for the synthesis of a novel magnetic nanocarrier via surface- initiated reversible addition-fragmentation chain transfer (RAFT) polymerization is introduced. At first, RAFT agent was successfully attached to the surface of Fe₃O₄ nanoparticles and, then, poly (glycidyl methacrylate) (PGMA) chains were grown and anchored onto the surface of Fe₃O₄ nanoparticles. At the end, hydrazine (Hy) groups were introduced to the PGMA chains via reaction between epoxy rings and hydrazine molecules. Doxorubicin (DOX) was covalently conjugated to the prepared nanocarrier (Fe₃O₄@PGMA@Hy) through a hydrazone linkage. The in vitro drug release of Fe₃O₄@PGMA@Hy@DOX examined in buffers with pH 7.4 and pH 5.4 exhibited a strong pH-sensitive behavior. The results showed that Fe₃O₄@PGMA@Hy@DOX successfully performed the delivery and controlled release of doxorubicin (DOX) anticancer drug.
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