Maximizing the oil content in polysaccharide-based emulsion gels for the development of tissue mimicking phantoms
2021
Fontes-Candia, Cynthia | Lopez-Sanchez, Patricia | Ström, Anna | Martínez, Juan Carlos | Salvador, Ana | Sanz, Teresa | Trefna, Hana Dobsicek | López-Rubio, Amparo | Martínez-Sanz, Marta
Formulations based on agar and κ-carrageenan were investigated for the production of emulsion gels applicable as tissue mimicking phantoms. The effects of the polysaccharide matrix, the oil content and the presence of surfactants on the micro-/nanostructure, rheology, and mechanical and dielectric properties were investigated. Results showed a high capacity of the agar to stabilize oil droplets, producing gels with smaller (10−21 μm) and more uniform oil droplets. The addition of surfactants allowed increasing the oil content and reduced the gel strength and stiffness down to 57 % and 34 %, respectively. The permittivity and conductivity of the gels were reduced by increasing the oil content, especially in the agar gels (18.8 and 0.05 S/m, respectively), producing materials with dielectric properties similar to those of low-water content tissues. These results evidence the suitability of these polysaccharides to design a variety of tissue mimicking phantoms with a broad range of mechanical and dielectric properties.
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