Chemical synthesis of new trypsin, chymotrypsin and elastase inhibitors by amino-acid substitutions in a trypsin inhibitor from squash seeds (CMTI III)

Rolka, K.; Kupryszewski, G.; Ragnarsson, U.; Otlewski, J.; Krokoszynska, I.; Wilusz, T.

Chemical synthesis of new trypsin, chymotrypsin and elastase inhibitors by amino-acid substitutions in a trypsin inhibitor from squash seeds (CMTI III)

1991

Five new analogues of squash trypsin inhibitor CMTI III were obtained by the solid-phase method, exhibiting antitrypsin, antichymotrypsin or antielastase activity. Modification in the reactive site region changes dramatically the specificity, whereas substitution in non-contact positions facilitates the refolding of the reduced form of the peptides and does not have a significant influence on the association equilibrium constants of the inhibitor analogues with cognate enzymes.

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AGROVOC关键词

analysis binding sites chemical synthesis chymotrypsin chymotrypsin cucurbita enzymology humans leukocytes peptides pharmacology seeds seeds synthesis trypsin inhibitors trypsin inhibitors

书目信息

发表于

Biological chemistry Hoppe-Seyler

卷 372 期 1 页码 63 - 68 ISSN 0177-3593

其它主题

Oxidation-reduction; Substrate specificity; Amino acid sequence; Analogs; X-ray diffraction; Elastase; Antagonists & inhibitors; Pancreatic elastase; Molecular sequence data

语言

英语

注释

Summary in german.

类型

Journal Article; Text

自何时收录于AGRIS: 2024-02-28

格式: MODS

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Chemical synthesis of new trypsin, chymotrypsin and elastase inhibitors by amino-acid substitutions in a trypsin inhibitor from squash seeds (CMTI III)

1991

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书目信息