Synthesis, conformational studies and anthelmintic activity of a constrained PF1022A analogue
1999
Scherkenbeck, J. | Dyker, H. | Gondol, D. | Harder, A. | Plant, A. | Reichel, F.
A mono-proline analogue of the potent anthelmintic cyclooctadepsipeptide PFIO22A has been synthesized. NMR studies in combination with molecular dynamics simulations demonstrate that the confirmation of this analogue is both rigidified and distorted compared with the asymmetric conformation of PF1022A. The backbone conformation is significant with respect to anthelmintic activity.
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书目信息
其它主题
Molecular conformation; Dose response; Animal parasitic nematodes
语言
英语
类型
Journal Article; Text
2024-02-28
MODS