In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect
2020
Andreani, Julien | Le Bideau, Marion | Duflot, Isabelle | Jardot, Priscilla | Rolland, Clara | Boxberger, Manon | Wurtz, Nathalie | Rolain, Jean-Marc | Colson, Philippe | La Scola, Bernard | Raoult, Didier
Human coronaviruses SARS-CoV-2 appeared at the end of 2019 and led to a pandemic with high morbidity and mortality. As there are currently no effective drugs targeting this virus, drug repurposing represents a short-term strategy to treat millions of infected patients at low costs. Hydroxychloroquine showed an antiviral effect in vitro. In vivo it showed efficacy, especially when combined with azithromycin in a preliminary clinical trial. Here we demonstrate that the combination of hydroxychloroquine and azithromycin has a synergistic effect in vitro on SARS-CoV-2 at concentrations compatible with that obtained in human lung.
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