2-Acetylthienopyridine Synthesis via Thiolation and Copper-Catalyzed Cyclization of o-Propynol Fluoropyridine Using Xanthate as a Thiol Surrogate
2018
Li, Yibiao | Luo, Xianglin | Shao, Yan | Chen, Lu
2-Acylthienopyridines and related heterocycles are readily prepared in moderate to good yields under mild conditions by a nucleophilic thiolation, copper-catalyzed cyclization, and an oxidation cascade process using potassium xanthate as the thiol source. Moreover, excellent chemoselectivity, broad substrate scope, and good functional group tolerance are prominent features of this transformation.
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书目信息
出版者
American Chemical Society
其它主题
Chemoselectivity; Organic chemistry; Lewis bases; Moieties
语言
英语
类型
Journal Article; Text
2024-02-28
MODS