Synthesis of fluorine-containing 3-hydroxyflavanones and isoflavones

Khlebnikova, T. S.; Piven′, Yu. A.; Khripach, N. B.; Lakhvich, F. A.

Synthesis of fluorine-containing 3-hydroxyflavanones and isoflavones

2011

Khlebnikova, T. S. | Piven′, Yu. A. | Khripach, N. B. | Lakhvich, F. A.

Fluorine-containing 3-hydroxyflavanones and isoflavones were synthesized by epoxidation of F-containing chalcones by hydrogen peroxide under basic conditions and subsequent intramolecular cyclization of the resulting epoxides using BF₃·Et₂O. The ratio of products depended on the presence and position of the F atom.

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