Proposed Epidemiological Cutoff Values for Ceftriaxone, Cefepime, and Colistin in Salmonella
2018
Tyson, Gregory H. | Bodeis-Jones, Sonya | Caidi, Hayat | Cook, Kimberly | Dessai, Uday | Haro, Jovita | McCullough, Andre E. | Meng, Jianghong | Morales, Cesar A. | Lawrence, Jodie Plumblee | Tillman, Glenn E. | Winslow, Angela | Miller, Ron A.
We tested a diverse set of 500 isolates of nontyphoidal Salmonella enterica subsp. enterica from various animal, food, and human clinical sources for susceptibility to antimicrobials currently lacking epidemiological cutoff values (ECOFFs) set by the European Committee on Antimicrobial Susceptibility Testing. A consortium of five different laboratories each tested 100 isolates, using broth microdilution panels containing twofold dilutions of ceftriaxone, cefepime, and colistin to determine the minimum inhibitory concentrations of each drug when tested against the Salmonella isolates. Based on the resulting data, new ECOFFs of 0.25 μg/mL for ceftriaxone, 0.12 μg/mL for cefepime, and 2 μg/mL for colistin have been proposed. These thresholds will aid in the identification of Salmonella that have phenotypically detectable resistance mechanisms to these important antimicrobials.
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