Visible-Light-Triggered Cyanoalkylation of para-Quinone Methides and Its Application to the Synthesis of GPR40 Agonists
2019
Zhang, Wei | Yang, Chen | Zhang, Zhi-Pei | Li, Xin | Cheng, Jin-Pei
Cyanoalkylated diarylmethanes with biological and pharmacological potentials were synthesized from para-quinone methides and cyanoalkylating reagents through a photocatalytic process. This protocol is operationally simple and mild and has high efficiency, which gave the corresponding products in moderate to good yields. The synthetic utility of this work has been illustrated in the efficient synthesis of GPR40 agonists, which play an important role in FA-induced glucose-sensitive insulin secretion.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
Organic letters
卷
21
期
11
页码
4137
- 4142
ISSN
1523-7052
出版者
American Chemical Society
其它主题
Insulin secretion; Photocatalysis
语言
英语
类型
Text; Journal Article
2024-02-28
MODS