Asymmetric Transfer Hydrogenation of Unhindered and Non-Electron-Rich 1-Aryl Dihydroisoquinolines with High Enantioselectivity
2020
Barrios-Rivera, Jonathan | Xu, Yingjian | Wills, Martin
The use of arene/Ru/TsDPEN catalysts bearing a heterocyclic group on the TsDPEN in the asymmetric transfer hydrogenation (ATH) of dihydroisoquinolines (DHIQs) containing meta- or para-substituted aromatic groups at the 1-position results in the formation of products of high enantiomeric excess. Previously, only 1-(ortho-substituted)aryl DHIQs, or with an electron-rich fused ring gave products with high enantioselectivity; therefore, this approach solves a long-standing challenge for imine ATH.
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书目信息
出版者
American Chemical Society
其它主题
Enantioselectivity; Imines
语言
英语
注释
Nal-ap-2-clean
类型
Journal Article; Text
2024-02-28
MODS