Serum C3 content in vitamin B12-deficient rats
1998
Wada, M. | Kawata, T. | Yamada, K. | Funada, U. | Kuwamori, M. | Endo, M. | Tanaka, N. | Tadokoro, T. | Maekawa, A.
As a clue to clarifying the role of vitamin B12 (B12) in the function of the complement system, serum C3 content was determined in B12-deficient rats, and the effect of the administration of methylcobalamin (CH3-B12) on the serum C3 content was also studied. It was found that the serum C3 content in rats fed on a vitamin B12-deficient diet for 90 and 120 days significantly decreased compared with that in control rats. The administration of CH3-B12 restored the serum C3 content to control levels. The above results indicate that B12-deficiency depressed the serum C3 content and lowered humoral immunocompetence, and that these changes were ascribable to B12-deficiency.
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