Combined Effects of a Buffer and Solvent on Tetramethylpyrazine Formation in a 3-Hydroxy-2-butanone/Ammonium Hydroxide System
1997
Huang, Tzou-Chi
A phosphate buffer was found to significantly promote tetramethylpyrazine (TMP) formation in an acetoin (3-hydroxy-2- butanone)/ammonium hydroxide system. The effect of the phosphate ion on TMP formation was additive in the range of 0.05–0.2 m. The change in pH value of the system reveals that a proton-coupled redox type of reaction occurred during TMP formation. Phosphate serves both as proton donor and acceptor to facilitate proton transfer during the Schiff base formation between ammonia and 3-hydroxy-2-butanone. Protic solvents, methanol, and ethanol, were found to attract the water released from the system. The combination of a phosphate buffer and protic solvent led to the completion of TMP formation. The TMP formation mechanism in a phosphate buffer (pH 7.2) is proposed.
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