Relationship of vitamins B-6 and B-12 to homocysteine levels: risk for coronary heart disease
1986
Swift, M.E. | Shultz, T.D.
Extract: There is evidence that homocysteine may be a factor in increasing the risk of coronary heart disease (CHD). To explore this relationship, we assessed the interrelations of dietary vitamins B-6, B-12, folate, plasma pyridoxal-5'-phosphate and vitamin B-12 with plasma free and protein-bound homocysteine levels. Fasting blood and three-day dietary records were obtained from nine men at low-risk (LR) and five at high-risk (HR) for CHD. The HR mean systolic blood pressure, total cholesterol (TC), and TC/HDL-cholesterol ratios were significantly higher than LR levels. No significant differenece was found for bound homocysteine between groups; however, free homocysteine differed significantly. Negative correlations were found between dietary vitamin B-6 and vitamin B-6:protein ratios with bound homocysteine and between plasma vitamin B-12 and free homocysteine. Although these data represent a small number of subjects, they suggest that bound and perhaps free homocysteine levels may be lowered by increased dietary vitamin B-6 and B-12 intake.(author)
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