One way to strengthen our knowledge on the effect of food on human health is to better understand the mechanisms of food disintegration in the gastrointestinal tract. During digestion, dietary proteins are hydrolyzed by digestive enzymes in the stomach and small intestine into a myriad of peptides. Peptidomic approaches have been developed in order to identify the peptides released in the lumen during in vitro and in vivo digestion by mainly using mass spectrometry. It has therefore been possible to demonstrate that peptides known to exert biological activities are present in the lumen at concentrations compatible with a biological action. However, this does not prove that the detected bioactive peptides have an effect on human health and more work is needed to determine peptide bioavailability and lifetime in the bloodstream. Thousands of peptides can be identified unambiguously and some efforts need to be done to develop new strategies of data treatment.
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出版者
Elsevier Ltd
其它主题
Dietary protein; Digestive enzymes
语言
英语
类型
Journal Article; Text
2024-02-28
2026-02-03
MODS