Saponins, which are present in plants, have been suggested as possible anticarcinogens. They possess surface-active characteristics that are due to the amphiphilic nature of their chemical structure. The proposed mechanisms of anticarcinogenic properties of saponins include direct cytotoxicity, immune-modulatory effects, bile acid binding and normalization of carcinogen-induced cell proliferation. However, the anticarcinogenic effects of saponins from commonly consumed plant foods have not been studied. Soybeans are one of the most important sources of dietary saponins. They are the main protein supplier in many vegetarian diets. Our results showed that soybean saponins at the concentration of 150-600 ppm had a dose-dependent growth inhibitory effect on human carcinoma cells (HCT-15). Viability was also significantly reduced. Soybean saponins did not increase cell membrane permeability in a dose-dependent fashion, whereas gypsophilla saponin, a nondietary saponin, increased permeability with increasing concentrations. Electron microscopy indicated that soybean and gypsophilla saponins alter cell morphology and interact with the cell membrane in different ways.
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Journal of nutrition
卷
125
期
35
ISSN
0022-3166
其它主题
Immunosuppression (physiological); Agave cantula; Gleditisia japonica; Structure-activity relationships; Asparagus curillus; Binding; Dose response; Quillaja saponaria; Asparagus (asparagaceae); Maxim franquet
语言
英语
注释
In the special issue: first international symposium on the role of soy in preventing and treating chronic disease / edited by m. messina and j.w. erdman. proceedings of a symposium held february 20-23, 1994, mesa, arizona.
2019-12-05
类型
Text; Journal Article
2024-02-28
MODS