Iron-Based Catalyst for Borylation of Unactivated Alkyl Halides without Using Highly Basic Organometallic Reagents

Siddiqui, Sheema; Bhawar, Ramesh; Geetharani, K.

Iron-Based Catalyst for Borylation of Unactivated Alkyl Halides without Using Highly Basic Organometallic Reagents

2020

Siddiqui, Sheema | Bhawar, Ramesh | Geetharani, K.

The mild borylation of alkyl bromides and chlorides with bis(neopentylglycolato)diborane (B₂neop₂) mediated by iron-bis amide is described. The reaction proceeds with a broad substrate scope and good functional group compatibility. Moreover, sufficient catalytic activity was obtained for primary and secondary alkyl halides. Mechanistic studies indicate that the reaction proceeds through a radical pathway.

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