Supported Gold Nanoparticle-Catalyzed Hydration of Alkynes under Basic Conditions

Liang, Shengzong; Jasinski, Jacek; Hammond, Gerald B.; Xu, Bo

Supported Gold Nanoparticle-Catalyzed Hydration of Alkynes under Basic Conditions

2015

Liang, Shengzong | Jasinski, Jacek | Hammond, Gerald B. | Xu, Bo

TiO₂-supported nanosize gold particles catalyze the hydration of alkynes using morpholine as a basic cocatalyst. Unlike most homogeneous cationic gold catalysts, the TiO₂–Au/morpholine system is weakly basic and is compatible with acid-sensitive functional groups (e.g., silyl ethers, ketals) or with a strongly coordinating group such as pyridine. What’s more, this gold catalyst can be recycled by simple filtration and works well in flow reactors.

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